Gene association to chromatin domain statistical analysis using Hi-C data

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Insight into the 3D organization of the genome, this question arises: Are the genes for the corresponding protein complexes, whose transcription needs to be orchestrated, located in the same 3D-chromatin domain? Using human protein complex database and high-resolution Hi-C data on normal and cancer human cells, I elaborated an R-based approach to normalize the data and statistically test the association to TAD (topologically associating domain) in my bioinformatics master's work.

chromatin Hi-C data genomics

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July 31, 2023

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