Abbott Alere ID NOW and Bhadra ... Ellington OSD-LAMP method
Great and very timely review. Nice to see it under version control too.
I was under the impression that the ID NOW PoC system was direct swab-to-reaction, in a sense extraction-free. Table S1 C16 suggests extraction is required. It looks like Abbott is amending their EUA to actually exclude UTM/VTM eluted samples (link to "ID NOW COVID-19 Technical Brief April 2020" on this page: https://www.alere.com/en/home/product-details/id-now-covid-19.html). Haven't looked to check if the LoD reported in the FDA EUA docs is from VTM/UTM or direct swab samples.
Might also be worth discussing the Bhadra ... Ellington's LAMP-OSD method that improves the LAMP sensitivity and specificity in a neat way: https://www.biorxiv.org/content/10.1101/2020.04.13.039941v1.full.pdf