Improve mosaicism filter
To reduce number of false positives (called as mosaic even if not true):
- In the Segregation filter, "parental mosaicism" should not be applied when the gene is annotated as "pure" AR (i.e., not mixed inheritance) in the gene panel. I.e., the rule should be "'parental mosaicism' NOT AR"
- Check parental genotypes; only one of the parents (with skewed allele ratio) should actually be called for the variant.
- Proband should have 0.1 higher allele ratio compared to the suspected mosaic parent
Original user request: MEET-169
Edited by Morten C. Eike