Version 2.1.0 is the second NLO version of Sherpa. The main new feature compared to the 2.0.x series is the automated simulation of spin-correlated decay chains. Additionally, Comix may be used for simulating H events in MC@NLO, which speeds up initialization times and runtimes. This release improves upon the previous series by an extension of its physics capabilities and an extensive validation of all features already present in the 2.0.x series.