Adjust ACMG rules using splice prediction
Background
Siphoned from #83 (closed). ACMG rules engine should be updated with using SpliceAI predictions for BP7 (REQ_no_splice_effect), PP3 and BP4
Note new guidelines are incoming, see &40, this will make this change deprecated.
Implementation
Use recommended thresholds for variants outside +/-1,2bp donor/acceptor sites from ClinGen SVI Splicing Subgroup (Walker et al. 2023):
- >=0.2 for PP3
- <=0.1 for BP4