ExtravDose

Project information

Extravasation Dose (ExtravDose) calculates local tissue dose from radiopharmaceutical extravasation during medical administration. The developed extravasation dosimetry model is a time-dependent, multi-dimensional, and multi-physics simulation that breaks the region into mesh/voxel volumes for analysis. It simulates the injection of a fluid with a defined activity concentration that is then transported throughout a region while accounting for mixing (i.e., concentration changes). With the transport of the concentrated fluid, a subsequent calculation of the spatial dependent dose rates and accumulated doses to tissue resulting from the fluid transport is determined. Models have been developed with the goal of focusing on ease of use for the end user in terms of the minimal number of required inputs while ensuring a reliable solution is obtained to help inform the decision-making process.

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About

Extravasation Dose (ExtravDose) is a module added to V+ in version 2.0 for calculating local tissue dose from radiopharmaceutical extravasation during medical administration. The developed extravasation dosimetry model is a time-dependent, multi-dimensional, and multi-physics simulation that breaks the region into mesh/voxel volumes for analysis. It simulates the injection of a fluid with a defined activity concentration that is then transported throughout a region while accounting for mixing (i.e., concentration changes). With the transport of the concentrated fluid, a subsequent calculation of the spatial dependent dose rates and accumulated doses to tissue resulting from the fluid transport is determined. Models have been developed with the goal of focusing on ease of use for the end user in terms of the minimal number of required inputs while ensuring a reliable solution is obtained to help inform the decision-making process. Users can perform quick approximations based on a minimal number of basic inputs (Basic mode) or in-depth assessments utilizing advanced modeling features with an expanded set of input parameters (Advanced mode).